Nicotinic Acetylcholine Receptor Clustering in DHA-Enriched Domains
نویسندگان
چکیده
منابع مشابه
The submembrane machinery for nicotinic acetylcholine receptor clustering
T HE segregation of membrane proteins into specialized domains is important for many aspects of cell function, especially those involving cell-cell interaction and conununication . Of particular interest to cellular and molecular neurobiologists are the highly specialized distributions of ion channels at synapses . Both the preand postsynaptic membranes exhibit organized arrays ofion channels t...
متن کاملBinding of perhydrohistrionicotoxin to intact and detergent-solubilized membranes enriched in nicotinic acetylcholine receptor.
A tritiated derivative of perhydrohistrionicotoxin was prepared and characterized and used in direct binding studies to membrane fragments from Torpedo californica electroplax. Perhydrohistrionicotoxin bound to a site distinct from the a-bungarotoxin and agonist binding sites in a ratio of one perhydrohistrionicotoxin bound per four a-bungarotoxin sites. In the presence of 10 pM carbamylcholine...
متن کاملEmbedded cholesterol in the nicotinic acetylcholine receptor.
The nicotinic acetylcholine receptor (nAChR) is a cation-selective channel central to both neuronal and muscular processes and is considered the prototype for ligand-gated ion channels, motivating a structural determination effort that spanned several decades [Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4 A resolution. J Mol Biol 346:967-989]. Purified nAChR must...
متن کاملIntegrin in Acetylcholine Receptor Clustering
The clustering of acetylcholine receptors (AChR) on skeletal muscle fibers is an early event in the formation of neuromuscular junctions. Recent studies show that laminin as well as agrin can induce AChR clustering. Since the a 7 b 1 integrin is a major laminin receptor in skeletal muscle, we determined if this integrin participates in laminin and/or agrin-induced AChR clustering. The alternati...
متن کاملDisclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor
Cholesterol influences ion-channel function, distribution and clustering in the membrane, endocytosis, and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report the occurrence of a cholesterol recognition motif, here coined "CARC", in the transmembrane regions of AChR subunits that bear extensive contact with the surrounding lipid, and are thus optimally suited to convey ch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.2338